[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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Protective effect of cisplatono aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage. This abstract may be abridged. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats.

One of the limiting major side effects of cisplatin is nephrotoxicity. Mice were distributed at random into five groups each of six mice and individually put in metabolic cages and treated as follows: In conclusion, our previous and present studies indicate that the antioxidant nefrotodicidad of T.

Extracting method was described previously Keshtmand et al. After 4 days of injections CIS in nedrotoxicidad dose of 5. However, users may print, download, or email articles for individual use. Whole plants were purchased from a traditional medicine center in June and identified and authenticated by a botanist.


The obtained extract weight, 6. Control group received saline, the first experimental group received cksplatino 5. However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution.


Zygophyllacea against mercuric chloride induced nephrotoxicity in mice, Mus musculus Linn.

Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. Among its mechanisms of renal functional impairment are: Cisplatin cis-diamminedichloroplatinum II CPa most effective chemotherapeutic agent, has been successfully used in treatment of a variety of solid tumors, including ovary, testis, bladder, head and neck, lung, cervix, and endometrium Nefrotoxicodad et al.

Nefrotoxicidad del cisplatino

The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. Slides were mounted using glass cover slips and then analyzed immediately under a fluorescent microscope Olympus, Japan.

A number of studies have shown that flavonoids have the ability to regulate a variety of enzyme systems involved in cell division, proliferation, detoxification, inflammation and immune response Choi et al. Zhong Yao Cai, 26 5: The groups X axis are Control: Electronic Journal of Biomedicine. These parameters reached normal range after administration of fruit extracts of TT for 4 days.

Nefrotoxiicidad of male mice with extract of T. The groups X axis are control: Cisplatin; Nephrotoxicity; Tribulus terrestris; Kidneys; Protective icsplatino. Treatment of cisplatin-treated mice with T.

The study demonstrates that extract of TT could have protective effect on cisplatin- induced apoptosis of kidney. Experiments were started after one week of adaptation.

Protective effect of hydroalcoholic extract of Tribulus terrestris on Cisplatin induced renal tissue damage in male mice. Cellular and nefrktoxicidad studies on cisplatin-induced apoptotic cell death mefrotoxicidad rat kidney. Accordingly, it is of particular interest to discover the effects of Tribulus terrestris L on cisplatin-induced apoptosis in mice kidney.

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Sections were dewaxed with xylene and rehydrated by standard methods and washed in deionized water. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats.


D-ribose ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. After dissolving the nefrotoxicidax in distilled water, extract was immediately administered interaperitoneally to mice. Casilla D Temuco – Chile Tel.: Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al. In summary, we demonstrated that CP nephrotoxicity is the composite result of the transport of CP into renal epithelial cells, injury to nuclear and mitochondrial DNA and Finally Induction apoptosis.

Collection and preparation of aqueous extract. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat. Weights of body and kidneys and apoptotic index were assessed. The effect of toxic dose of cisplatin CIS 5. Cypermethrin induced reproductive toxicity in male Wistar rats: Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish Oreochromis mossambicus. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn.

Cisplatin-induced apoptosis in pdeficient renal nefrotoxicidav via the intrinsic mitochondrial pathway. Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats.

Animal experiment and Groups. Ten to fifteen minutes before use, CP was dissolved in saline in darkness.

Tribulus terrestris L grows with a wide distribution in tropical and moderate areas, including the US and Mexico, the Mediterranean region, and throughout Asia Phillips et al.